We need to assure that client work continues while you are out. When planning a PTO, you need to inform all your clients about the time you are off. All clients need to agree to your time off period and accept that at the most one round of revisions or one request can be actively conducted in that period of time and that no deliverables can be expected until 24 hours after the creative director is back from leave.
If any of your clients for whatever reason cannot accept the vacation period, you need to find and brief a substitute Creative Director.